英语翻译Synthesis and Structure of Trigonal and Tetragonal Conne

英语翻译
Synthesis and Structure of Trigonal and Tetragonal Connectors
for a “Tinkertoy” Construction Set
Peter F.H.Schwab,Bruce C.Noll,and Josef Michl*
Department of Chemistry and Biochemistry,University of Colorado,Boulder,Colorado 80309-0215
michl@eefus.colorado.edu
Received February 15,2002
We describe a convergent synthesis of eight 1,3,5- and 1,2,4,5-substituted benzene derivatives with
long rigid arms containing 4-pyridyl,2,2¢-bipyridyl,and 2,2¢-bipyrimidyl termini,meant to be used
as trigonal or tetragonal connectors for the construction of large molecular structures.The synthesis
involved copper-free Pd-mediated coupling of terminal acetylenes to aryl halides.First,one of the
termini of 1,3-diethynylbicyclo[1.1.1]pentane was coupled with a brominated aza heterocycle,and
second,3 equiv of the resulting extended arm were coupled with 1,3,5-triiodobenzene or 4 with
1,2,4,5-tetraiodobenzene.An improved large-scale synthesis for 1,3-diethynylbicyclo[1.1.1]pentane
is described.The structures of two of the arms were determined by single-crystal X-ray analysis.
Several long molecular rods with 4-pyridyl termini were obtained as byproducts,and a singlecrystal
X-ray structure is reported for the shortest of these.

合成和结构三角和四角连接器
一个“ Tinkertoy ”建设集
彼得跳频施瓦布,布鲁斯角诺尔和约瑟夫Michl *
化学与生物化学系,科罗拉多大学,科罗拉多州博尔德80309-0215
michl@eefus.colorado.edu
收到2002年2月15号
我们描述一个收敛合成8 1,3,5 -和1,2,4,5 -取代苯衍生物的
长期僵化的武器载4 -吡啶,2,2 ¢ -联吡啶和2,2 ¢ - bipyrimidyl总站,是用来
作为三方或四方连接器,用于建造大型分子结构.综合
参与铜免费钯介导耦合的终端炔以卤代芳烃.首先,一个
总站的1,3 - diethynylbicyclo [ 1.1.1 ]戊烷是加上溴化杂环字,并
第二,3相当于由此产生的延长臂被加上1,3,5 triiodobenzene或4
1,2,4,5 - tetraiodobenzene .一种改进的大规模合成1,3 - diethynylbicyclo [ 1.1.1 ]戊烷
描述.结构的两个武器,测定了单晶X射线衍射分析.
一些长期分子杆4 -吡啶基总站,得到的副产品,以及singlecrystal
X -射线结构是报告中最短的这些.